These 2022-2025 research priorities emerged from a year-long process which included a comprehensive environment scan of: 1) the strategic plans of federal agencies and major foundations; 2) a survey from OT stakeholders including researchers and clinicians; and 3) focus groups with OT researchers. Data from the environmental scan was reviewed by the AOTF Scientific Advisory Council and AOTF Board. Input was also obtained from other AOTF's key stakeholder groups prior to the development and/or revisions of the final priorities. Future AOTF research initiatives will address these priorities to support our vision of having a vibrant science that builds knowledge to support effective, evidence-based occupational therapy.